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Baicalin

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    Baicalin is a traditional Chinese herbal medicine commonly used for hair loss, the precise molecular mechanism of which is not clearly understood. [In a recent study, the mechanism of baicalin was investigated via the topical application of baicalin to reconstituted hair follicles on mice. The results indicate that baicalin stimulates the expression of Wnt3α, Wnt5α, frizzled 7 and dishevelled 2 receptors whilst inhibiting the Axin/casein kinase 1α/adenomatous polyposis coli/glycogen synthase kinase 3β degradation complex, leading to accumulation of β-catenin and activation of Wnt/β-catenin signaling. In addition, baicalin was observed to increase the alkaline phosphatase levels in dermal papilla cells, a process which was dependent on Wnt pathway activation.] Given its non-toxicity and ease of topical application, baicalin represents a promising treatment for alopecia and other forms of hair loss. This product can be used once a day.
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